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ENBREL is injected just under the skin with a needle in a part of the body that is easy to reach. The best places are the front of your thighs, your abdomen (not too close to the belly button) or outside of your upper arms. Pick a different injection site every time – at least 3 cm from an old site.

When injecting, remember that you need a firm surface to push against. So if you are using the abdomen, for example, you may need to pinch the skin before injecting.

Note: this is particularly important if using the Auto-injector, which has a safety mechanism that requires a small amount of pressure to be applied before injection.


Step-by-step injection demos

You or a caregiver should receive training from your healthcare professional for the first injection of ENBREL. Click below to view step-by-step instructions.

The most common side effect is a mild reaction in the area where ENBREL was injected, including: itching, bruising, redness, bleeding, swelling, pain or hardness around the injection site. These reactions generally do not occur as often after the first month of treatment.

If you are concerned about injection site reactions, contact your healthcare professional.

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Consumer Medicine Information

Each ENBREL presentation is accompanied by a specific Consumer Medicine Information (CMI) sheet that explains in detail how to inject your ENBREL. Please read the instructions carefully and follow them step by step. Your doctor or nurse will instruct you on the techniques of self-injection, or on giving an injection to a child, using the form of injection that has been prescribed for you. This information should be used as a quick reminder guide only. You should make sure that you have read your CMI sheet and are confident that you understand how to inject ENBREL before you begin. Further help and instructions are available on request, please call 0800 ENBREL (0800 362 735).



Always use the sharps container provided to dispose of used Auto-injectors or syringes. When the sharps container is filled to the maximum level marked on the container, the lid should be securely closed in preparation for disposal. It is important not to exceed the fill level at any time. Ask your local hospital or pharmacy for a list of medical waste disposal points. Swabs and cotton balls can be placed in the garbage unless otherwise instructed by your doctor, nurse or pharmacist. Keep out of the reach of children. To order a new sharps bin, please call 0800 ENBREL (0800 362 735).